1. What is the estimate h^2? The broad-sense heritability for sickle cell anemia is low, but the narrow-sense heritability for sickle cell anemia is high.
2. How much does selection act on this Trait? In general, selection would strengthen the heritability and reproduction of this trait, mainly because due to reproductive success causes malaria/sickle-cell anemia to persist and adapt within a population. For example, if the virus mutates, it will respond in regards to selection in which what occurs on one loci affects the frequency of alleles occurring on the second locus, making it occur more frequently in the population. Since the narrow-sense heritability is high, then this eliminates the contribution of dominance within its genetic variation.
3. What effect would inbreeding have on this trait? Since Malaria, or sickle cell anemia rather, is an autosomal recessive trait we would expect inbreeding to increase the number of people with "full blown" sickle cell anemia. Inbreeding usually tends to bring out autosomal recessive diseases.
